Photocytotoxicity of a 5-nitrofuran-ethenyl-quinoline antiseptic (Quinifuryl) to P388 mouse leukemia cells

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Photocytotoxicity of a 5-nitrofuran-ethenyl-quinoline antiseptic (Quinifuryl) to P388 mouse leukemia cells.

Quinifuryl (MW 449.52), 2-(5'-nitro-2'-furanyl)ethenyl-4-[N-[4'-(N,N-diethylamino)-1'-methylbutyl]carbamoyl] quinoline, is a water soluble representative of a family of 5-nitrofuran-ethenyl-quinoline drugs which has been shown to be highly toxic to various lines of transformed cells in the dark. In the present study, the toxicity of Quinifuryl to P388 mouse leukemia cells was compared in the da...

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When tumor cells are chronically treated with antitumor drugs such as vinca alkaloids or anthracyclines, they often acquire resistance not only to the same drugs but also to other antitumor drugs1~3). Although the mechanism of this pleiotropic drug resistance is not fully understood, decreased uptake and retention of doxorubicin ( = adriamycin, ADM) and daunorubicin ( = daunomycin, DNR) in drug...

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Characterization of a Rana catesbeiana lectin-resistant mutant of leukemia P388 cells.

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2004

ISSN: 0100-879X

DOI: 10.1590/s0100-879x2004001200013